What is 5-Amino-1MQ?
5-Amino-1MQ is a small-molecule compound (not a peptide), developed as an inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular energy balance and metabolic regulation. By inhibiting NNMT, it is thought to preserve nicotinamide for NAD+ synthesis rather than conversion into methylated metabolites. It emerged from research into obesity and metabolic disorders. Unlike peptide-based agents, 5-amino-1MQ acts through targeted enzyme inhibition, with preclinical studies suggesting potential effects on fat metabolism, energy expenditure, and body composition.
What is 5-Amino-1MQ Used for?
Potential research applications of 5-Amino-1MQ include:
- Weight management and obesity research
- Fat metabolism and fat cell function
- Regulating energy and caloric expenditure
- NAD+ metabolism and nicotinamide pathway research
Side Effects of 5-Amino-1MQ
5-Amino-1MQ has demonstrated a favorable safety profile in preclinical studies. It has generally been described as well tolerated over short study periods, without clear evidence of major toxicity at the doses evaluated. Reported effects have focused more on metabolic changes than on a consistent side-effect profile.
5-Amino-1MQ Dosing Protocol (for Research)
Because human clinical dosing has not been established, the following should be viewed as a translational research framework rather than a validated human regimen:
| Phase | Dose & frequency |
|---|---|
| Week 1 | 0.5 - 1 mg daily |
| Weeks 2-3 | 2 mg daily |
| Week 4 and beyond | Up to 5 mg daily |
Shown for education. A licensed clinician should set any actual dose. Compare protocols across peptides in the peptide dosage chart.
Common questions about 5-Amino-1MQ
What is 5-Amino-1MQ?
5-Amino-1MQ is a small-molecule compound (not a peptide), developed as an inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular energy balance and metabolic regulation. By inhibiting NNMT, it is thought to preserve nicotinamide for NAD+ synthesis rather than conversion into methylated metabolites.
What is 5-Amino-1MQ used for?
Areas studied include: Weight management and obesity research; Fat metabolism and fat cell function; Regulating energy and caloric expenditure; NAD+ metabolism and nicotinamide pathway research.
What are the side effects of 5-Amino-1MQ?
5-Amino-1MQ has demonstrated a favorable safety profile in preclinical studies. It has generally been described as well tolerated over short study periods, without clear evidence of major toxicity at the doses evaluated.
What is the dosage of 5-Amino-1MQ?
One commonly referenced research protocol is: Week 1: 0.5 - 1 mg daily; Weeks 2-3: 2 mg daily; Week 4 and beyond: Up to 5 mg daily. Shown for education only; a licensed clinician should set any actual dose. See the dosing table.
How do you mix (reconstitute) 5-Amino-1MQ?
Wipe the vial tops with alcohol, add bacteriostatic water slowly so it runs down the inside of the glass, then roll the vial gently until the powder dissolves; don’t shake it. See the step-by-step guide with diagrams for the pen and syringe methods.
How much bacteriostatic water do you add to 5-Amino-1MQ?
There is no single correct amount. We recommend 2.1 mL: about 0.1 mL is lost during transfer, leaving roughly 2.0 mL of usable solution. You can add more or less (most peptide vials hold up to 3 mL); just enter the amount in the dose calculator. See the step-by-step mixing guide.
Is 5-Amino-1MQ FDA-approved?
No. 5-Amino-1MQ is not FDA-approved in the US (status as of October 2026).
References
- Neelakantan H, et al. Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase. J Med Chem. 2017;60:5015-28. View source
- Neelakantan H, et al. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem Pharmacol. 2019;163:481-92. View source
- Awosemo O, Neelakantan H, Watowich S, Ma J, et al. Development & validation of LC-MS/MS assay for 5-amino-1-methyl quinolinium in rat plasma: Application to pharmacokinetic and oral bioavailability studies. J Pharm Biomed Anal. 2021;204:114255.